This study proposes a high voltage gain pulse power supply based on the Sepic-Marx circuit, addressing the demands for compactness, portability, and high step-up ratios in low-voltage DC-powered applications such as outdoor portable devices and plasma propulsion. The topology integrates the Sepic structure with the classic Marx generator, retaining its modular design while utilizing Sepic inductors as isolation components to suppress rapid changes of input current. The working principle is analyzed, dividing each switching cycle into four operational modes: inductor charging preparation, high-voltage pulse output, capacitor charging with voltage pumping, and a waiting state. Simulation results in PSIM software show that a five-stage circuit achieves a pulse output of 1.7kV with a 10kHz repetition frequency and 5μs pulse width under a 50V input, yielding a voltage gain of 34. Compared with classical Marx and Boost-Marx generators, the proposed topology requires fewer stages to achieve the same gain, demonstrating distinct advantages in voltage step-up capability and modular simplicity.