Multiphase open-winding motor drive is a new type of motor drive with high DC voltage utilization rate and strong fault tolerance ability. However, common mode voltage and its associated common mode electromagnetic noise and axial current still exist, which will harm power electronic devices and transmission systems. In this paper, a space vector pulse width modulation (SVPWM) technique is proposed to suppress the common mode voltage and common mode electromagnetic interference of the six-phase open-winding driven by a single power supply. Based on the vector space decoupling theory, a six-phase open-winding permanent magnet synchronous motor is established to analyze the causes of common mode voltage and zero-sequence current in the driving system. When synthesizing the target vector, the common mode voltage and zero-sequence current are eliminated by only switching the space voltage vector which does not generate common mode voltage and zero-sequence current. The voltage vector in one harmonic subspace is eliminated by the opposite direction of the space voltage vector output by two inverters, and the average voltage in the other harmonic subspace is eliminated by multi-vector synthesis. Designed a dead zone compensation algorithm for the dead zone problem. The simulation results show that the proposed algorithm can not only eliminate the zero-sequence current and harmonics, but also effectively suppress common mode voltage, shaft current and common mode electromagnetic interference.