This paper proposes a DC/DC converter using differential load-independent Class E inverter. It explores the design methodology of the differential load-independent Class E inverter. With proper parameter design, the load-sensitivity issue of the traditional Class E inverters is addressed, and high efficiency conversion could be maintained for a wide load range. In order to validate the design method, an isolated inductive power transfer system is built with a full-bridge rectifier at the secondary side. Both the simulation and experiment are given to verify the system characteristics. Constant output and high-efficiency operation are achieved under a wide load range.