Considering the uncertainty of the internal parameters of high-speed train and the influence of external disturbances, based on the generalized internal-mode control framework (GIMC), H2 control and µ-synthesis methods are used to design a nominal controller that satisfies tracking performance and a robust controller with rejection to disturbances, respectively. A dynamic model of a high-speed train with internal uncertain parameters coupled by multiple carriages via train couplers and subject to air resistance, mechanical resistance and sudden gust disturbances is established. The corresponding controller is designed by the above method, and the dynamic model of CRH2 high-speed train is simulated to verify the tracking performance and anti-disturbance performance of the control design.