As more and more powerful electronic devices are connected to the aircraft power system, the load power of the system presents pulsating characteristics. To make the aircraft high-voltage DC power supply system meet the power demand with pulsating load, an optimized configuration of the aircraft 270V high-voltage DC power supply system based on two-stage filter distribution is proposed. According to the response characteristics of the power supply, the two-stage filtering distribution strategy is adopted to determine the power of each power supply response; A comprehensive optimal configuration model considering the weight and efficiency of the power supply system and the constraints that the power supply operation system needs to meet is established; The particle swarm optimization algorithm is used to solve the model; By comparing the optimal configuration results of the power system with the two distribution strategies of the generator response average power and two-stage filtering through the calculation example, the configuration results show that the overall weight of the power system is reduced by 115.2kg and the system efficiency is increased by 12.21% by using the method in this paper. The optimization results reflect the advantages of the method in this paper, and the simulation analysis verifies the correctness of the configuration results.